Drug interactions
Ergotamine + Sumatriptan intranasal
Severity: Contraindicated
Ergotamine and Sumatriptan intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs constrict blood vessels through serotonin receptor activity, so combined use may produce additive vasospasm, including coronary and peripheral ischemia. Prolonged vasospastic reactions have been described with ergot and triptan combinations.
What this interaction means in plain words
Ergotamine and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive 5-HT1B/1D-mediated vasoconstriction.
What to do
Do not use within 24 hours of each other; choose one agent per migraine episode.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Sumatriptan intranasal?
MediHelp rates the interaction as contraindicated. Ergotamine and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs constrict blood vessels through serotonin receptor activity, so combined use may produce additive vasospasm, including coronary and peripheral ischemia. Prolonged vasospastic reactions have been described with ergot and triptan combinations.
How serious is the interaction between Ergotamine and Sumatriptan intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of each other; choose one agent per migraine episode.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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