Drug interactions
Ergotamine + Telotristat ethyl
Severity: Minor
Ergotamine and Telotristat ethyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl may induce CYP3A4 and lower ergotamine exposure. This could reduce the antimigraine effect.
What this interaction means in plain words
Ergotamine and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Telotristat induces CYP3A4, increasing ergotamine clearance.
What to do
Monitor for loss of migraine control. Consider an alternative acute treatment if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Telotristat ethyl?
MediHelp rates the interaction as minor. Ergotamine and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat ethyl may induce CYP3A4 and lower ergotamine exposure. This could reduce the antimigraine effect.
How serious is the interaction between Ergotamine and Telotristat ethyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of migraine control. Consider an alternative acute treatment if efficacy falls.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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