Drug interactions
Ergotamine + Trifluoperazine
Severity: Moderate
Ergotamine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic activity, and antipsychotics may add to serotonergic or dopamine-blocking effects. Serotonin syndrome or neuroleptic malignant syndrome is theoretically possible but uncommon.
What this interaction means in plain words
Ergotamine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic effects; the mechanism is not firmly established.
What to do
Monitor for confusion, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity. Stop both drugs and treat if these appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergotamine and Trifluoperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Trifluoperazine?
MediHelp rates the interaction as moderate. Ergotamine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic activity, and antipsychotics may add to serotonergic or dopamine-blocking effects. Serotonin syndrome or neuroleptic malignant syndrome is theoretically possible but uncommon.
How serious is the interaction between Ergotamine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity. Stop both drugs and treat if these appear.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
