Drug interactions
Ergotamine + Turmeric
Severity: Minor
Ergotamine and Turmeric: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Curcumin in turmeric may inhibit CYP3A4 in vitro and could modestly raise ergotamine exposure. Clinical evidence is limited, but ergotamine toxicity is serious.
What this interaction means in plain words
Ergotamine and Turmeric have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by curcuminoids reduces ergotamine metabolism.
What to do
Culinary amounts need no action. Advise patients to avoid high-dose turmeric or curcumin supplements and report numbness, tingling or cold extremities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Turmeric?
MediHelp rates the interaction as minor. Ergotamine and Turmeric have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Curcumin in turmeric may inhibit CYP3A4 in vitro and could modestly raise ergotamine exposure. Clinical evidence is limited, but ergotamine toxicity is serious.
How serious is the interaction between Ergotamine and Turmeric?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Culinary amounts need no action. Advise patients to avoid high-dose turmeric or curcumin supplements and report numbness, tingling or cold extremities.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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