Drug interactions
Eribulin + Fluvoxamine
Severity: Moderate
Eribulin and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and fluvoxamine may add to this effect, increasing arrhythmia risk in susceptible patients. The overall contribution from fluvoxamine is likely small.
What this interaction means in plain words
Eribulin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes, particularly in the first treatment cycles. Avoid in patients with congenital long QT syndrome or other major QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Fluvoxamine?
MediHelp rates the interaction as moderate. Eribulin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and fluvoxamine may add to this effect, increasing arrhythmia risk in susceptible patients. The overall contribution from fluvoxamine is likely small.
How serious is the interaction between Eribulin and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, particularly in the first treatment cycles. Avoid in patients with congenital long QT syndrome or other major QT risk factors.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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