Drug interactions
Eribulin + Gemifloxacin
Severity: Major
Eribulin and Gemifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and gemifloxacin has a similar liability, so together they raise the risk of torsades de pointes. Patients with heart failure, bradycardia, or electrolyte abnormalities are particularly vulnerable.
What this interaction means in plain words
Eribulin and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive delay of cardiac repolarization.
What to do
Choose a non-QT-prolonging antibiotic where possible. If both are used, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Gemifloxacin?
MediHelp rates the interaction as major. Eribulin and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval and gemifloxacin has a similar liability, so together they raise the risk of torsades de pointes. Patients with heart failure, bradycardia, or electrolyte abnormalities are particularly vulnerable.
How serious is the interaction between Eribulin and Gemifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-QT-prolonging antibiotic where possible. If both are used, monitor ECG and electrolytes.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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