Drug interactions
Eribulin + Granisetron
Severity: Moderate
Eribulin and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and granisetron has a smaller QT effect. Used together they may add to the risk of ventricular arrhythmia, especially with electrolyte disturbances. Chemotherapy-related vomiting makes electrolyte loss more likely.
What this interaction means in plain words
Eribulin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT interval prolongation.
What to do
Check ECG at baseline and periodically, and correct hypokalemia and hypomagnesemia. Avoid the combination in congenital long QT syndrome, or use an antiemetic with less QT effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Granisetron?
MediHelp rates the interaction as moderate. Eribulin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval and granisetron has a smaller QT effect. Used together they may add to the risk of ventricular arrhythmia, especially with electrolyte disturbances. Chemotherapy-related vomiting makes electrolyte loss more likely.
How serious is the interaction between Eribulin and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and periodically, and correct hypokalemia and hypomagnesemia. Avoid the combination in congenital long QT syndrome, or use an antiemetic with less QT effect.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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