Drug interactions
Eribulin + Hydroxyzine
Severity: Major
Eribulin and Hydroxyzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is associated with QT prolongation and torsades de pointes, and eribulin also lengthens the QT interval. Combined use may increase arrhythmia risk, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Eribulin and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Hydroxyzine belongs to Respiratory.
Why it happens
Additive QTc prolongation (pharmacodynamic).
What to do
Use a non-QT-prolonging antiemetic or antihistamine where possible; otherwise monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Eribulin with Hydroxyzine?
MediHelp rates the interaction as major. Eribulin and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydroxyzine is associated with QT prolongation and torsades de pointes, and eribulin also lengthens the QT interval. Combined use may increase arrhythmia risk, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Eribulin and Hydroxyzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antiemetic or antihistamine where possible; otherwise monitor ECG and correct potassium and magnesium.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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