Drug interactions
Eribulin + Loperamide
Severity: Moderate
Eribulin and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong the QT interval, so combined use may increase risk of torsades de pointes. Loperamide is often used for eribulin-associated diarrhea, so doses should stay within limits.
What this interaction means in plain words
Eribulin and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Use loperamide at labeled doses only and monitor ECG in patients with QT risk factors. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Loperamide?
MediHelp rates the interaction as moderate. Eribulin and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong the QT interval, so combined use may increase risk of torsades de pointes. Loperamide is often used for eribulin-associated diarrhea, so doses should stay within limits.
How serious is the interaction between Eribulin and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide at labeled doses only and monitor ECG in patients with QT risk factors. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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