Drug interactions
Eribulin + Macimorelin
Severity: Major
Eribulin and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin, a diagnostic agent for growth hormone deficiency, causes a small QT increase, and eribulin may add to it. Coadministration may increase the risk of torsades de pointes.
What this interaction means in plain words
Eribulin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Postpone the macimorelin test until eribulin has been cleared, or use an alternative diagnostic. Do not combine them without ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Macimorelin
Frequently asked questions
Can I take Eribulin with Macimorelin?
MediHelp rates the interaction as major. Eribulin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin, a diagnostic agent for growth hormone deficiency, causes a small QT increase, and eribulin may add to it. Coadministration may increase the risk of torsades de pointes.
How serious is the interaction between Eribulin and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone the macimorelin test until eribulin has been cleared, or use an alternative diagnostic. Do not combine them without ECG monitoring.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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