Drug interactions
Eribulin + Moxifloxacin
Severity: Major
Eribulin and Moxifloxacin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and moxifloxacin adds to this effect, raising the risk of torsades de pointes. Risk is higher in patients with electrolyte abnormalities or heart failure.
What this interaction means in plain words
Eribulin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation affecting cardiac repolarization.
What to do
Use an alternative antibiotic where possible. If both are needed, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Avelox 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: other medicinal products that may prolong the QTc interval; "An additive effect on QT interval prolongation of moxifloxacin and other medicinal products that may prolong the QTc interval cannot be excluded.") — electronic medicines compendium (UK SmPC)
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Moxifloxacin?
MediHelp rates the interaction as major. Eribulin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and moxifloxacin adds to this effect, raising the risk of torsades de pointes. Risk is higher in patients with electrolyte abnormalities or heart failure.
How serious is the interaction between Eribulin and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If both are needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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