Drug interactions
Eribulin + Osilodrostat
Severity: Moderate
Eribulin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and osilodrostat can also cause hypokalemia. Combined use increases the risk of torsades de pointes.
What this interaction means in plain words
Eribulin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation, with osilodrostat-related hypokalemia.
What to do
Perform a baseline ECG and monitor ECG and potassium and magnesium during treatment. Correct electrolyte abnormalities promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Osilodrostat
Frequently asked questions
Can I take Eribulin with Osilodrostat?
MediHelp rates the interaction as moderate. Eribulin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs prolong the QT interval, and osilodrostat can also cause hypokalemia. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Eribulin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor ECG and potassium and magnesium during treatment. Correct electrolyte abnormalities promptly.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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