Drug interactions
Eribulin + Osimertinib
Severity: Moderate
Eribulin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may raise the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Eribulin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Osimertinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes periodically and correct abnormalities. Withhold or reduce osimertinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Osimertinib
Frequently asked questions
Can I take Eribulin with Osimertinib?
MediHelp rates the interaction as moderate. Eribulin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may raise the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or heart disease.
How serious is the interaction between Eribulin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct abnormalities. Withhold or reduce osimertinib if QTc becomes markedly prolonged.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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