Drug interactions
Eribulin + Perphenazine
Severity: Major
Eribulin and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and perphenazine has additional QT-prolonging potential. Using them together may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Eribulin and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation.
What to do
Check ECG and electrolytes at baseline and periodically during eribulin therapy, correcting potassium and magnesium abnormalities. Consider an alternative to perphenazine if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Perphenazine?
MediHelp rates the interaction as major. Eribulin and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and perphenazine has additional QT-prolonging potential. Using them together may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Eribulin and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically during eribulin therapy, correcting potassium and magnesium abnormalities. Consider an alternative to perphenazine if the QTc becomes significantly prolonged.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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