Drug interactions
Eribulin + Rilpivirine
Severity: Moderate
Eribulin and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and eribulin can also lengthen QT. Combined use may raise the risk of arrhythmia, especially in patients with other risk factors.
What this interaction means in plain words
Eribulin and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Rilpivirine belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes during eribulin treatment. Consider another antiretroviral if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Eribulin with Rilpivirine?
MediHelp rates the interaction as moderate. Eribulin and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and eribulin can also lengthen QT. Combined use may raise the risk of arrhythmia, especially in patients with other risk factors.
How serious is the interaction between Eribulin and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes during eribulin treatment. Consider another antiretroviral if QTc is prolonged.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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