Drug interactions
Eribulin + Selinexor
Severity: Moderate
Eribulin and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, fatigue and confusion, and eribulin can cause peripheral neuropathy and fatigue. Together they may worsen neurological and functional toxicity, though no direct interaction is established.
What this interaction means in plain words
Eribulin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Selinexor belongs to Oncology.
Why it happens
Overlapping adverse effects; no specific pharmacokinetic or pharmacodynamic mechanism established.
What to do
Monitor for dizziness, confusion, neuropathy and fatigue, and counsel patients on fall and driving risks. Reduce or hold doses of either drug if neurological toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Eribulin with Selinexor?
MediHelp rates the interaction as moderate. Eribulin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, fatigue and confusion, and eribulin can cause peripheral neuropathy and fatigue. Together they may worsen neurological and functional toxicity, though no direct interaction is established.
How serious is the interaction between Eribulin and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion, neuropathy and fatigue, and counsel patients on fall and driving risks. Reduce or hold doses of either drug if neurological toxicity develops.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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