Drug interactions
Eribulin + Solifenacin
Severity: Moderate
Eribulin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and solifenacin has a minor additive effect. Arrhythmia risk is greater with electrolyte abnormalities or heart failure.
What this interaction means in plain words
Eribulin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor the ECG and correct hypokalemia and hypomagnesemia before and during eribulin therapy. Consider an alternative to solifenacin if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Solifenacin?
MediHelp rates the interaction as moderate. Eribulin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval and solifenacin has a minor additive effect. Arrhythmia risk is greater with electrolyte abnormalities or heart failure.
How serious is the interaction between Eribulin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and correct hypokalemia and hypomagnesemia before and during eribulin therapy. Consider an alternative to solifenacin if the QTc becomes prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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