Drug interactions
Eribulin + Tacrolimus
Severity: Major
Eribulin and Tacrolimus: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so concurrent use may increase the risk of ventricular arrhythmia. Tacrolimus-induced hypomagnesemia and hypokalemia can further add to the risk.
What this interaction means in plain words
Eribulin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation, potentially worsened by tacrolimus-related electrolyte loss.
What to do
Obtain baseline and follow-up ECGs and monitor tacrolimus levels, potassium and magnesium; replace electrolytes as needed and consider alternatives if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eribulin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Eribulin with Tacrolimus?
MediHelp rates the interaction as major. Eribulin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so concurrent use may increase the risk of ventricular arrhythmia. Tacrolimus-induced hypomagnesemia and hypokalemia can further add to the risk.
How serious is the interaction between Eribulin and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and monitor tacrolimus levels, potassium and magnesium; replace electrolytes as needed and consider alternatives if QTc rises significantly.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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