Drug interactions
Eribulin + Vemurafenib
Severity: Major
Eribulin and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin and vemurafenib can each prolong the QT interval. Used together they may increase the risk of torsades de pointes, especially in patients with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Eribulin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid combining them if an alternative exists. If used together, monitor ECG and electrolytes at baseline and periodically, and stop or reduce a drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eribulin and Vemurafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eribulin
Other interactions of Vemurafenib
Frequently asked questions
Can I take Eribulin with Vemurafenib?
MediHelp rates the interaction as major. Eribulin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin and vemurafenib can each prolong the QT interval. Used together they may increase the risk of torsades de pointes, especially in patients with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Eribulin and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them if an alternative exists. If used together, monitor ECG and electrolytes at baseline and periodically, and stop or reduce a drug if QTc becomes markedly prolonged.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
