Drug interactions
Erlotinib + Fluvoxamine
Severity: Moderate
Erlotinib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib is metabolized mainly by CYP3A4 and partly by CYP1A2, and fluvoxamine inhibits CYP1A2 strongly and CYP3A4 weakly. Erlotinib exposure may increase, raising the risk of rash, diarrhea and other dose-related toxicity.
What this interaction means in plain words
Erlotinib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP1A2 and CYP3A4, reducing erlotinib clearance.
What to do
Monitor for rash, diarrhea and interstitial lung symptoms, and reduce the erlotinib dose stepwise if severe reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Fluvoxamine?
MediHelp rates the interaction as moderate. Erlotinib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erlotinib is metabolized mainly by CYP3A4 and partly by CYP1A2, and fluvoxamine inhibits CYP1A2 strongly and CYP3A4 weakly. Erlotinib exposure may increase, raising the risk of rash, diarrhea and other dose-related toxicity.
How serious is the interaction between Erlotinib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash, diarrhea and interstitial lung symptoms, and reduce the erlotinib dose stepwise if severe reactions occur.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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