Drug interactions
Erlotinib + Iloperidone
Severity: Minor
Erlotinib and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has weak CYP3A4 inhibiting activity and may modestly raise erlotinib concentrations. Clinical effect is likely small.
What this interaction means in plain words
Erlotinib and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erlotinib belongs to Oncology; Iloperidone belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by iloperidone reduces erlotinib metabolism.
What to do
No routine adjustment needed. Monitor for erlotinib adverse effects such as rash and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Erlotinib with Iloperidone?
MediHelp rates the interaction as minor. Erlotinib and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has weak CYP3A4 inhibiting activity and may modestly raise erlotinib concentrations. Clinical effect is likely small.
How serious is the interaction between Erlotinib and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed. Monitor for erlotinib adverse effects such as rash and diarrhea.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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