Drug interactions
Erlotinib + Voriconazole
Severity: Moderate
Erlotinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase erlotinib exposure, raising the risk of dose-related toxicities such as rash, diarrhea and interstitial lung disease. The effect is expected from the role of CYP3A4 in erlotinib clearance.
What this interaction means in plain words
Erlotinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, which is the main pathway of erlotinib metabolism.
What to do
Monitor for erlotinib toxicity such as severe diarrhea or rash, and reduce the erlotinib dose in steps if it occurs. Consider an alternative antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Voriconazole?
MediHelp rates the interaction as moderate. Erlotinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase erlotinib exposure, raising the risk of dose-related toxicities such as rash, diarrhea and interstitial lung disease. The effect is expected from the role of CYP3A4 in erlotinib clearance.
How serious is the interaction between Erlotinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity such as severe diarrhea or rash, and reduce the erlotinib dose in steps if it occurs. Consider an alternative antifungal if feasible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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