Drug interactions
Erythromycin + Etravirine
Severity: Moderate
Erythromycin and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower erythromycin levels, while erythromycin may modestly raise etravirine exposure. The net effect is possible loss of antibacterial effect and altered antiretroviral exposure, though it is not a true contraindication.
What this interaction means in plain words
Erythromycin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 while erythromycin inhibits it, giving bidirectional pharmacokinetic changes.
What to do
Monitor clinical response to erythromycin and consider azithromycin if treatment failure is a concern. Monitor for etravirine adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Erythromycin with Etravirine?
MediHelp rates the interaction as moderate. Erythromycin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower erythromycin levels, while erythromycin may modestly raise etravirine exposure. The net effect is possible loss of antibacterial effect and altered antiretroviral exposure, though it is not a true contraindication.
How serious is the interaction between Erythromycin and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to erythromycin and consider azithromycin if treatment failure is a concern. Monitor for etravirine adverse effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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