Drug interactions
Erythromycin + Fluvoxamine
Severity: Moderate
Erythromycin and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, so concurrent use may increase the risk of ventricular arrhythmias. Fluvoxamine also inhibits CYP3A4 to some degree, which may raise erythromycin levels.
What this interaction means in plain words
Erythromycin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by fluvoxamine increasing erythromycin exposure.
What to do
Monitor the ECG and correct potassium and magnesium; choose an alternative antibiotic if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Erythromycin with Fluvoxamine?
MediHelp rates the interaction as moderate. Erythromycin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, so concurrent use may increase the risk of ventricular arrhythmias. Fluvoxamine also inhibits CYP3A4 to some degree, which may raise erythromycin levels.
How serious is the interaction between Erythromycin and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and correct potassium and magnesium; choose an alternative antibiotic if other QT risk factors are present.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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