Drug interactions
Erythromycin + Granisetron
Severity: Moderate
Erythromycin and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and use together may increase the risk of torsades de pointes. The risk is higher in patients with electrolyte disturbances or receiving other QT-prolonging drugs such as chemotherapy.
What this interaction means in plain words
Erythromycin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Check ECG and correct potassium and magnesium in higher risk patients. Consider a non-macrolide antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Frequently asked questions
Can I take Erythromycin with Granisetron?
MediHelp rates the interaction as moderate. Erythromycin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and use together may increase the risk of torsades de pointes. The risk is higher in patients with electrolyte disturbances or receiving other QT-prolonging drugs such as chemotherapy.
How serious is the interaction between Erythromycin and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium in higher risk patients. Consider a non-macrolide antibiotic.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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