Drug interactions
Erythromycin + Iloperidone
Severity: Major
Erythromycin and Iloperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase iloperidone levels by inhibiting CYP3A4, and both agents can prolong the QT interval. This raises the risk of arrhythmia and iloperidone adverse effects such as sedation and orthostasis.
What this interaction means in plain words
Erythromycin and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Iloperidone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition raises iloperidone exposure, with additive QT prolongation.
What to do
Prefer a non-interacting antibiotic. If combined, monitor the ECG and electrolytes and consider reducing the iloperidone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Erythromycin with Iloperidone?
MediHelp rates the interaction as major. Erythromycin and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase iloperidone levels by inhibiting CYP3A4, and both agents can prolong the QT interval. This raises the risk of arrhythmia and iloperidone adverse effects such as sedation and orthostasis.
How serious is the interaction between Erythromycin and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-interacting antibiotic. If combined, monitor the ECG and electrolytes and consider reducing the iloperidone dose.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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