Drug interactions
Erythromycin + Lasmiditan
Severity: Moderate
Erythromycin and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein and may raise concentrations of P-gp substrates such as erythromycin. The clinical effect is likely modest but could increase erythromycin adverse effects including QT effects.
What this interaction means in plain words
Erythromycin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, increasing absorption of erythromycin.
What to do
Monitor for erythromycin adverse effects such as gastrointestinal upset or palpitations. Consider an alternative antibiotic in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Erythromycin with Lasmiditan?
MediHelp rates the interaction as moderate. Erythromycin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-glycoprotein and may raise concentrations of P-gp substrates such as erythromycin. The clinical effect is likely modest but could increase erythromycin adverse effects including QT effects.
How serious is the interaction between Erythromycin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin adverse effects such as gastrointestinal upset or palpitations. Consider an alternative antibiotic in patients with QT risk factors.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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