Drug interactions
Erythromycin + Macimorelin
Severity: Major
Erythromycin and Macimorelin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin prolongs the QT interval modestly, and erythromycin does as well. Combined use raises the risk of torsade de pointes during the diagnostic test.
What this interaction means in plain words
Erythromycin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Macimorelin belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Avoid macimorelin testing while on erythromycin; defer the test until erythromycin has been stopped and cleared.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin and Macimorelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Erythromycin with Macimorelin?
MediHelp rates the interaction as major. Erythromycin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin prolongs the QT interval modestly, and erythromycin does as well. Combined use raises the risk of torsade de pointes during the diagnostic test.
How serious is the interaction between Erythromycin and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while on erythromycin; defer the test until erythromycin has been stopped and cleared.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
