Drug interactions
Erythromycin + Osilodrostat
Severity: Moderate
Erythromycin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so used together they may increase the risk of torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia, bradycardia or underlying heart disease.
What this interaction means in plain words
Erythromycin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor it during coadministration, correcting potassium and magnesium abnormalities. Prefer a non-QT-prolonging antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Erythromycin with Osilodrostat?
MediHelp rates the interaction as moderate. Erythromycin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so used together they may increase the risk of torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia, bradycardia or underlying heart disease.
How serious is the interaction between Erythromycin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during coadministration, correcting potassium and magnesium abnormalities. Prefer a non-QT-prolonging antibiotic if possible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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