Drug interactions
Erythromycin + Pomalidomide
Severity: Minor
Erythromycin and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is a P-glycoprotein substrate and erythromycin inhibits P-gp, so exposure may rise slightly. The expected effect is modest and unlikely to be clinically significant in most patients.
What this interaction means in plain words
Erythromycin and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Pomalidomide belongs to Miscellaneous.
Why it happens
Erythromycin inhibits P-glycoprotein efflux, which may modestly increase pomalidomide exposure.
What to do
No dose change is usually needed; monitor for hematologic toxicity as part of routine pomalidomide care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Erythromycin with Pomalidomide?
MediHelp rates the interaction as minor. Erythromycin and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is a P-glycoprotein substrate and erythromycin inhibits P-gp, so exposure may rise slightly. The expected effect is modest and unlikely to be clinically significant in most patients.
How serious is the interaction between Erythromycin and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for hematologic toxicity as part of routine pomalidomide care.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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