Drug interactions
Erythromycin + Rimegepant
Severity: Moderate
Erythromycin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can increase rimegepant exposure, raising the potential for adverse effects such as nausea and hypersensitivity reactions. The combination is generally manageable by avoiding repeated dosing.
What this interaction means in plain words
Erythromycin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Rimegepant belongs to Central Nervous System.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, both involved in rimegepant elimination.
What to do
Avoid a second rimegepant dose within 48 hours when taken with a moderate CYP3A4 inhibitor. Consider an alternative antibiotic if frequent dosing is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Erythromycin with Rimegepant?
MediHelp rates the interaction as moderate. Erythromycin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can increase rimegepant exposure, raising the potential for adverse effects such as nausea and hypersensitivity reactions. The combination is generally manageable by avoiding repeated dosing.
How serious is the interaction between Erythromycin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with a moderate CYP3A4 inhibitor. Consider an alternative antibiotic if frequent dosing is needed.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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