Drug interactions
Erythromycin + Saxagliptin
Severity: Minor
Erythromycin and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly increase saxagliptin exposure because saxagliptin is metabolized by CYP3A4/5. The effect of moderate inhibitors is typically small and rarely clinically important.
What this interaction means in plain words
Erythromycin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Saxagliptin belongs to Endocrine.
Why it happens
CYP3A4 inhibition by erythromycin decreases saxagliptin metabolism.
What to do
No dose change is usually needed; monitor glycemic control and for adverse effects. The saxagliptin dose limit applies mainly to strong CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Erythromycin with Saxagliptin?
MediHelp rates the interaction as minor. Erythromycin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may modestly increase saxagliptin exposure because saxagliptin is metabolized by CYP3A4/5. The effect of moderate inhibitors is typically small and rarely clinically important.
How serious is the interaction between Erythromycin and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor glycemic control and for adverse effects. The saxagliptin dose limit applies mainly to strong CYP3A4 inhibitors.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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