Drug interactions
Erythromycin + Tazemetostat
Severity: Major
Erythromycin and Tazemetostat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and can raise tazemetostat exposure. Higher tazemetostat levels may increase the risk of adverse effects such as cytopenias and other dose-related toxicities.
What this interaction means in plain words
Erythromycin and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Tazemetostat belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tazemetostat by erythromycin.
What to do
Prefer a non-CYP3A4-inhibiting antibiotic such as a non-macrolide alternative. If coadministration is unavoidable, reduce the tazemetostat dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Erythromycin with Tazemetostat?
MediHelp rates the interaction as major. Erythromycin and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin is a moderate CYP3A4 inhibitor and can raise tazemetostat exposure. Higher tazemetostat levels may increase the risk of adverse effects such as cytopenias and other dose-related toxicities.
How serious is the interaction between Erythromycin and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting antibiotic such as a non-macrolide alternative. If coadministration is unavoidable, reduce the tazemetostat dose per labeling and monitor for toxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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