Drug interactions
Erythromycin base + Fexofenadine
Severity: Minor
Erythromycin base and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin raises fexofenadine plasma concentrations by roughly a modest degree through transporter inhibition. Unlike with some other antihistamines, no clinically meaningful QT effect has been shown with fexofenadine.
What this interaction means in plain words
Erythromycin base and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits P-gp and OATP-mediated transport of fexofenadine, increasing absorption and reducing clearance.
What to do
No dose adjustment is generally needed; watch for increased antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Erythromycin base with Fexofenadine?
MediHelp rates the interaction as minor. Erythromycin base and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin raises fexofenadine plasma concentrations by roughly a modest degree through transporter inhibition. Unlike with some other antihistamines, no clinically meaningful QT effect has been shown with fexofenadine.
How serious is the interaction between Erythromycin base and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; watch for increased antihistamine adverse effects.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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