Drug interactions
Erythromycin base + Indacaterol
Severity: Moderate
Erythromycin base and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-glycoprotein, which modestly increases indacaterol systemic exposure. Erythromycin also prolongs the QT interval, so cardiac effects may be additive. The increase in exposure was not considered clinically significant at the usual dose.
What this interaction means in plain words
Erythromycin base and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces indacaterol clearance, along with additive QT prolongation.
What to do
No indacaterol dose adjustment is generally needed at the standard dose; monitor for tachycardia, tremor and palpitations, and check ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin base and Indacaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indacaterol
Frequently asked questions
Can I take Erythromycin base with Indacaterol?
MediHelp rates the interaction as moderate. Erythromycin base and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and P-glycoprotein, which modestly increases indacaterol systemic exposure. Erythromycin also prolongs the QT interval, so cardiac effects may be additive. The increase in exposure was not considered clinically significant at the usual dose.
How serious is the interaction between Erythromycin base and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No indacaterol dose adjustment is generally needed at the standard dose; monitor for tachycardia, tremor and palpitations, and check ECG in patients with QT risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
