Drug interactions
Erythromycin base + Insulin degludec-insulin aspart
Severity: Minor
Erythromycin base and Insulin degludec-insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolides such as erythromycin have been rarely associated with hypoglycemia in patients receiving glucose-lowering drugs. Clinical significance with insulin is small and evidence is limited.
What this interaction means in plain words
Erythromycin base and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not firmly established; erythromycin may stimulate insulin release through motilin-related and gastric emptying effects.
What to do
Be aware of the possibility of hypoglycemia and check glucose if symptoms occur during erythromycin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Erythromycin base with Insulin degludec-insulin aspart?
MediHelp rates the interaction as minor. Erythromycin base and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolides such as erythromycin have been rarely associated with hypoglycemia in patients receiving glucose-lowering drugs. Clinical significance with insulin is small and evidence is limited.
How serious is the interaction between Erythromycin base and Insulin degludec-insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the possibility of hypoglycemia and check glucose if symptoms occur during erythromycin therapy.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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