Drug interactions
Erythromycin base + Ruxolitinib
Severity: Moderate
Erythromycin base and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may increase ruxolitinib exposure. This can worsen cytopenias such as thrombocytopenia and neutropenia.
What this interaction means in plain words
Erythromycin base and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of ruxolitinib.
What to do
Monitor blood counts more frequently and reduce the ruxolitinib dose if cytopenias develop. Consider a non-interacting antibiotic such as azithromycin where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Frequently asked questions
Can I take Erythromycin base with Ruxolitinib?
MediHelp rates the interaction as moderate. Erythromycin base and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and may increase ruxolitinib exposure. This can worsen cytopenias such as thrombocytopenia and neutropenia.
How serious is the interaction between Erythromycin base and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts more frequently and reduce the ruxolitinib dose if cytopenias develop. Consider a non-interacting antibiotic such as azithromycin where appropriate.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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