Drug interactions
Erythromycin ethylsuccinate + Indacaterol
Severity: Moderate
Erythromycin ethylsuccinate and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can raise systemic indacaterol exposure, and both drugs can prolong the QT interval. Increased beta-agonist exposure may cause tachycardia, tremor and hypokalemia, and the combined QT effect may raise arrhythmia risk in susceptible patients.
What this interaction means in plain words
Erythromycin ethylsuccinate and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, which reduces indacaterol clearance, and both drugs have additive QT-prolonging effects.
What to do
At the usual 75 mcg dose no adjustment is generally required, but monitor heart rate, potassium and symptoms of beta-agonist excess. Obtain an ECG if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Indacaterol?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can raise systemic indacaterol exposure, and both drugs can prolong the QT interval. Increased beta-agonist exposure may cause tachycardia, tremor and hypokalemia, and the combined QT effect may raise arrhythmia risk in susceptible patients.
How serious is the interaction between Erythromycin ethylsuccinate and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At the usual 75 mcg dose no adjustment is generally required, but monitor heart rate, potassium and symptoms of beta-agonist excess. Obtain an ECG if the patient has other QT risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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