Drug interactions
Erythromycin ethylsuccinate + Palbociclib
Severity: Moderate
Erythromycin ethylsuccinate and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and can raise palbociclib plasma concentrations. Higher exposure may increase myelosuppression, particularly neutropenia.
What this interaction means in plain words
Erythromycin ethylsuccinate and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of palbociclib, reducing its clearance.
What to do
Prefer an alternative antibiotic that does not inhibit CYP3A4, such as azithromycin if appropriate. If combined, monitor blood counts closely and consider reducing the palbociclib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Palbociclib?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and can raise palbociclib plasma concentrations. Higher exposure may increase myelosuppression, particularly neutropenia.
How serious is the interaction between Erythromycin ethylsuccinate and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic that does not inhibit CYP3A4, such as azithromycin if appropriate. If combined, monitor blood counts closely and consider reducing the palbociclib dose.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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