Drug interactions
Erythromycin ethylsuccinate + Sevoflurane
Severity: Moderate
Erythromycin ethylsuccinate and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can prolong the QT interval and cause torsades de pointes, especially with other risk factors. Sevoflurane adds to QTc prolongation.
What this interaction means in plain words
Erythromycin ethylsuccinate and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through blockade of cardiac potassium channels.
What to do
Check QTc and electrolytes before anesthesia in patients on erythromycin. Monitor the ECG during the procedure or choose a non-macrolide antibiotic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Sevoflurane?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can prolong the QT interval and cause torsades de pointes, especially with other risk factors. Sevoflurane adds to QTc prolongation.
How serious is the interaction between Erythromycin ethylsuccinate and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check QTc and electrolytes before anesthesia in patients on erythromycin. Monitor the ECG during the procedure or choose a non-macrolide antibiotic if QTc is prolonged.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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