Drug interactions
Erythromycin stearate + Goserelin
Severity: Moderate
Erythromycin stearate and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can prolong QT and cause torsades de pointes, and goserelin may add to the effect. The risk is higher with electrolyte disturbance, heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Erythromycin stearate and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider a non-macrolide alternative in patients with QT risk factors. Otherwise obtain an ECG and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Frequently asked questions
Can I take Erythromycin stearate with Goserelin?
MediHelp rates the interaction as moderate. Erythromycin stearate and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can prolong QT and cause torsades de pointes, and goserelin may add to the effect. The risk is higher with electrolyte disturbance, heart disease or other QT-prolonging drugs.
How serious is the interaction between Erythromycin stearate and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-macrolide alternative in patients with QT risk factors. Otherwise obtain an ECG and correct potassium and magnesium.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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