Drug interactions
Erythromycin stearate + Palbociclib
Severity: Moderate
Erythromycin stearate and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin stearate can inhibit intestinal and hepatic CYP3A4 and raise palbociclib concentrations. Increased exposure may worsen neutropenia and other palbociclib toxicities.
What this interaction means in plain words
Erythromycin stearate and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of palbociclib, reducing its clearance.
What to do
Choose an alternative antibiotic without CYP3A4 inhibition when feasible. Otherwise monitor blood counts closely and adjust the palbociclib dose according to neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Frequently asked questions
Can I take Erythromycin stearate with Palbociclib?
MediHelp rates the interaction as moderate. Erythromycin stearate and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin stearate can inhibit intestinal and hepatic CYP3A4 and raise palbociclib concentrations. Increased exposure may worsen neutropenia and other palbociclib toxicities.
How serious is the interaction between Erythromycin stearate and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antibiotic without CYP3A4 inhibition when feasible. Otherwise monitor blood counts closely and adjust the palbociclib dose according to neutropenia.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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