Drug interactions
Erythromycin stearate + Tiotropium-olodaterol
Severity: Moderate
Erythromycin stearate and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can prolong the QT interval and beta2 agonists such as olodaterol can add cardiac effects including hypokalemia and tachycardia. Together they may raise the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Erythromycin stearate and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation increasing arrhythmia susceptibility.
What to do
Check baseline ECG and correct potassium and magnesium before combining, and monitor for palpitations or syncope. Consider a non-macrolide antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Erythromycin stearate with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Erythromycin stearate and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can prolong the QT interval and beta2 agonists such as olodaterol can add cardiac effects including hypokalemia and tachycardia. Together they may raise the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Erythromycin stearate and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before combining, and monitor for palpitations or syncope. Consider a non-macrolide antibiotic in patients with other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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