Drug interactions
Escitalopram + Fedratinib
Severity: Moderate
Escitalopram and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6, which may raise escitalopram concentrations. Higher levels increase the risk of serotonergic effects and QT prolongation.
What this interaction means in plain words
Escitalopram and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP2C19 and CYP3A4 by fedratinib, reducing escitalopram clearance.
What to do
Monitor for escitalopram toxicity and consider dose reduction, particularly when starting fedratinib. Obtain an ECG if risk factors for QT prolongation are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Escitalopram with Fedratinib?
MediHelp rates the interaction as moderate. Escitalopram and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4, CYP2C19 and CYP2D6, which may raise escitalopram concentrations. Higher levels increase the risk of serotonergic effects and QT prolongation.
How serious is the interaction between Escitalopram and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram toxicity and consider dose reduction, particularly when starting fedratinib. Obtain an ECG if risk factors for QT prolongation are present.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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