Drug interactions
Escitalopram + Fenfluramine
Severity: Major
Escitalopram and Fenfluramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine releases serotonin, and combining it with an SSRI raises the risk of serotonin syndrome. Labeling advises caution with serotonergic agents.
What this interaction means in plain words
Escitalopram and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Escitalopram belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity through serotonin release by fenfluramine and reuptake inhibition by escitalopram.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, especially after dose increases. Stop one or both drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Escitalopram with Fenfluramine?
MediHelp rates the interaction as major. Escitalopram and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenfluramine releases serotonin, and combining it with an SSRI raises the risk of serotonin syndrome. Labeling advises caution with serotonergic agents.
How serious is the interaction between Escitalopram and Fenfluramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability, especially after dose increases. Stop one or both drugs if serotonin syndrome is suspected.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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