Drug interactions
Escitalopram + Idelalisib
Severity: Moderate
Escitalopram and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib strongly inhibits CYP3A4 and may raise escitalopram exposure, which could increase dose-related adverse effects including QT prolongation and serotonergic toxicity. Escitalopram is cleared by several enzymes (CYP2C19, CYP3A4, CYP2D6), so the rise is likely modest.
What this interaction means in plain words
Escitalopram and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of escitalopram by idelalisib.
What to do
Monitor for increased escitalopram adverse effects and ECG changes, and reduce the escitalopram dose if they appear. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Escitalopram with Idelalisib?
MediHelp rates the interaction as moderate. Escitalopram and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib strongly inhibits CYP3A4 and may raise escitalopram exposure, which could increase dose-related adverse effects including QT prolongation and serotonergic toxicity. Escitalopram is cleared by several enzymes (CYP2C19, CYP3A4, CYP2D6), so the rise is likely modest.
How serious is the interaction between Escitalopram and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased escitalopram adverse effects and ECG changes, and reduce the escitalopram dose if they appear. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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