Drug interactions
Escitalopram + Modafinil
Severity: Minor
Escitalopram and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may inhibit CYP2C19 and could modestly raise escitalopram exposure, though modafinil also induces some enzymes so the net effect is uncertain. Clinical significance is expected to be small.
What this interaction means in plain words
Escitalopram and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Possible CYP2C19 inhibition by modafinil reducing escitalopram clearance, with competing weak enzyme induction.
What to do
No routine dose change; monitor for escitalopram adverse effects such as nausea, insomnia or QT-related symptoms and adjust the dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Escitalopram with Modafinil?
MediHelp rates the interaction as minor. Escitalopram and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil may inhibit CYP2C19 and could modestly raise escitalopram exposure, though modafinil also induces some enzymes so the net effect is uncertain. Clinical significance is expected to be small.
How serious is the interaction between Escitalopram and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for escitalopram adverse effects such as nausea, insomnia or QT-related symptoms and adjust the dose if they emerge.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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