Drug interactions
Escitalopram + Tiotropium-olodaterol
Severity: Moderate
Escitalopram and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Escitalopram prolongs the QT interval in a dose-related way and olodaterol may add to this effect. The risk of ventricular arrhythmia is greater with high doses, hypokalemia or cardiac disease.
What this interaction means in plain words
Escitalopram and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta2-mediated potassium lowering.
What to do
Keep escitalopram at the lowest effective dose and check an ECG if risk factors are present. Monitor potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Escitalopram and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Escitalopram prolongs the QT interval in a dose-related way and olodaterol may add to this effect. The risk of ventricular arrhythmia is greater with high doses, hypokalemia or cardiac disease.
How serious is the interaction between Escitalopram and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep escitalopram at the lowest effective dose and check an ECG if risk factors are present. Monitor potassium and magnesium.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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