Drug interactions
Escitalopram + Triclabendazole
Severity: Moderate
Escitalopram and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole and its metabolites inhibit CYP2C19, a key enzyme in escitalopram clearance, which may increase escitalopram exposure. Higher levels raise the risk of dose-related QT prolongation and other adverse effects.
What this interaction means in plain words
Escitalopram and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19 by triclabendazole reduces escitalopram metabolism.
What to do
Monitor for escitalopram adverse effects during the short triclabendazole course and consider an ECG if QT risk factors are present. Reduce the escitalopram dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Escitalopram with Triclabendazole?
MediHelp rates the interaction as moderate. Escitalopram and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole and its metabolites inhibit CYP2C19, a key enzyme in escitalopram clearance, which may increase escitalopram exposure. Higher levels raise the risk of dose-related QT prolongation and other adverse effects.
How serious is the interaction between Escitalopram and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram adverse effects during the short triclabendazole course and consider an ECG if QT risk factors are present. Reduce the escitalopram dose if toxicity occurs.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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