Drug interactions
Escitalopram + Valbenazine
Severity: Moderate
Escitalopram and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, particularly at higher doses or exposures. Together they may increase the risk of QT prolongation and torsades de pointes in susceptible patients.
What this interaction means in plain words
Escitalopram and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Check an ECG in patients with cardiac disease, bradycardia or electrolyte abnormalities. Correct potassium and magnesium, and keep escitalopram at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Escitalopram with Valbenazine?
MediHelp rates the interaction as moderate. Escitalopram and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, particularly at higher doses or exposures. Together they may increase the risk of QT prolongation and torsades de pointes in susceptible patients.
How serious is the interaction between Escitalopram and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG in patients with cardiac disease, bradycardia or electrolyte abnormalities. Correct potassium and magnesium, and keep escitalopram at the lowest effective dose.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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